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个人简介



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  • 性别：男
  • 职称：研究员
  • 学历：博士
  • 学科：微生物学
个人简历

3354cc金沙集团主页研究员，国家高层次青年人才计划入选者（2022），广东省青年珠江学者（2019）。从事呼吸道微生物组研究，应用多组学技术及疾病动物模型探究慢阻肺等慢性呼吸系统疾病菌群—宿主互作机制。以通讯或第一作者在Nature Medicine，Cell Host & Microbe，Nature Microbiology，American Journal of Respiratory and Critical Care Medicine，ISME Journal等期刊发表SCI论文50余篇，H-index为28。主持十四五国家重点研发计划课题，国自然面上项目等多项。担任中国医疗保健国际交流促进会临床微生物学会委员、广东省生物化学与分子生物学学会青年委员会副主任委员、广东省精准医学应用协会微生态医学分会常务委员、广东省精准医学应用协会精准健康管理分会常务委员、广东省慢阻肺康复工程技术研究中心委员、广东省生物科学普及协会副理事长兼秘书长等职务。担任Medicine in Microecology，iMeta期刊青年编委。


教育经历
2009年毕业于武汉大学获生物学学士学位， 2014年于美国弗吉尼亚大学获得微生物学博士学位
研究方向
本课题组聚焦于人体呼吸道微生物组。人体呼吸道菌群参与重大呼吸疾病发生发展，是近年关注焦点。慢性呼吸系统疾病呼吸道菌群发生失调，但菌群与疾病因果关系未知，菌群宿主互作机制仍待阐明。慢性阻塞性肺疾病（慢阻肺）是重要慢性呼吸系统疾病，其全球患病和死亡率长期处于前三位。近90%慢阻肺患者未能得到明确诊断，造成了重大社会负担。我们前期研究：①发现气道菌群可区分慢阻肺关键表型，揭示菌群宿主炎症关联现象（Eur Respir J. 2016，Thorax. 2018）；②阐明气道菌群与慢阻肺炎症内型关系，发现慢阻肺基于气道菌群特征新亚群，提出“菌群—炎症”联合分型新模式（Am J Respir Crit Care Med. 2021）；③建立多组学分析新方法，绘制慢阻肺菌群与宿主关联网络（ISME J. 2020），阐明菌群宿主互作机制（Nat Microbiol. 2022，Cell Host Microbe. 2023）；④揭示环境污染暴露通过呼吸道菌群紊乱影响呼吸健康，识别早期慢阻肺发生的呼吸道菌群风险因子（Nat Med. 2023）。以上研究呼吸道微生物组作为呼吸疾病新型生物标志物及潜在干预靶标提供科学依据。
讲授课程
生物信息学、博士英语、组学与生物信息学、生态基因组学
承担课题
代表性课题： 1. 十四五国家重点研发计划课题，《呼吸道微生物组数据收集及分析方法学研究》，370万元，2022YFA1304301，主持，2022.12-2027.11 2. 国家自然科学基金面上项目，《慢性阻塞性肺疾病气道菌群失调促进脓毒症急性肺损伤的机制探索》，58万元，32170109，主持，2022.1-2025.12 3. 国家自然科学基金面上项目，《多组学技术联合解析慢阻肺急性加重气道微生物组宿主互作机制》，62万元，31970112，主持，2020.1-2023.12
论文专著

代表性论文：

1.      Lin L#1, Yi X1, Liu H1, Meng R1, Li S, Liu X, Yang J, Xu Y, Li C, Wang Y, Xiao N, Li H, Liu Z, Xiang Z, Shu W, Guan WJ#, Zheng XY#, Sun J#, Wang Z#. The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans. 2023. Nature Medicine. Jul;29(7):1750-1759. doi: 10.1038/s41591-023-02424-2

2.      Liang W1, Yang Y1, Gong S1, Wei M1, Ma Y1, Feng R, Gao J, Liu X, Tu F, Ma W, Yi X, Liang Z, Wang F, Wang L, Chen D, Shu W, Miller BE, Tal-Singer R, Donaldson GC, Wedzicha JA, Singh D, Wilkinson TMA, Brightling CE, Chen R, Zhong N, Wang Z#. Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease. 2023. Cell Host & Microbe. May 16:S1931-3128(23)00167-1. doi: 10.1016/j.chom.2023.04.018 (期刊配发Editorial述评)

3.      Yan Z1, Chen B1, Yang Y1, Yi X1, Wei M1, Ecklu-Mensah G, Bushmann M, Liu H, Gao J, Liang W, Liu X, Yang J, Ma W, Liang Z, Wang F, Chen D, Wang L, Shi W, Stampfli MR, Li P, Gong S, Chen X, Shu W, El-Omar EM, Gilbert JA, Blaser MJ, Zhou H#, Chen R#, Wang Z#. Multi-omics analyses of airway host-microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions. Nature Microbiology. 2022. Sep;7(9):1361-1375. doi: 10.1038/s41564-022-01196-8 (期刊配发Research Briefing)

4.      Wang Z#, Locantore N, Haldar K, Ramsheh MY, Beech AS, Ma W, Brown JR, Tal-Singer R, Barer MR, Bafadhel M, Donaldson GC, Wedzicha JA, Singh D, Wilkinson TMA, Miller BE, Brightling CE. Inflammatory Endotype Associated Airway Microbiome in COPD Clinical Stability and Exacerbations – A Multi-Cohort Longitudinal Analysis. American Journal of Respiratory and Critical Care Medicine. 2021 Jun 15;203(12):1488-1502 (ESI高被引论文)

5.      Wang Z1, Bafadhel M1, Haldar K, Spivak A, Mayhew D, Miller BE, Tal-Singer R, Johnston SL, Ramsheh MY, Barer MR, Brightling CE, Brown JR. 2016. Lung microbiome dynamics in chronic obstructive pulmonary disease exacerbations. European Respiratory Journal. Apr;47(4):1082-92. (ESI高被引论文)

6.      Wang Z1#, Yang Y1, Yan Z1, Liu H, Chen B, Liang Z, Wang F, Miller BE, Tal-Singer R, Yi X, Li J, Stampfli MR, Zhou H, Brightling CE, Brown JR, Wu M, Chen R, Shu W. Multi-omic meta-analysis identifies functional signatures of airway microbiome in chronic obstructive pulmonary disease. The ISME Journal. 2020 Nov;14(11):2748-2765 (F1000 Prime推荐)

7.      Wang Z1, Singh R1, Miller BE, Tal-Singer R, Van Horn S, Tomsho L, Mackay A, Allinson JP, Webb AJ, Brookes AJ, George LM, Barker B, Kolsum U, Donnelly LE, Belchamber K, Barnes PJ, Singh D, Brightling CE, Donaldson GC, Wedzicha JA, Brown JR on behalf of COPDMAP. 2018. Sputum microbiome temporal variability and dysbiosis in chronic obstructive pulmonary disease exacerbations: an analysis of the COPDMAP study. Thorax. Apr;73(4):331-338

 

其他论文：

1.      Yi XZ1, Yang JH1, Huang 1Y, Han XR1, Li HM1, Cen LJ, Lin ZH, Pan CX, Wang Z#, Guan WJ#. Differential airway resistome and its correlations with clinical characteristics in Haemophilus- or Pseudomonas-predominant microbial subtypes of bronchiectasis. Respiratory Research 24, 264 (2023). https://doi.org/10.1186/s12931-023-02562-8

2.      Gao J, Yi X, Wang Z#. The application of multi-omics in the respiratory microbiome: Progresses, challenges and promises. Comput Struct Biotechnol J 2023 Oct 12:21:4933-4943.doi: 10.1016/j.csbj.2023.10.016.

3.      Yang L, Li N, Yi X, Wang Z#. The translational potential of the lung microbiome as a biomarker and a therapeutic target for chronic obstructive pulmonary disease. Interdisplinary Medicine. 2023. https://doi.org/10.1002/INMD.20230023

4.      Yi X, Cai H, Gao J, Wang Z#. Environmental exposure, airway microbiome and respiratory health: you are what you breathe. Clinical and Translational Medicine. 2023. Sep;13(9):e1394. doi: 10.1002/ctm2.1394

5.      Li N1, Yi X1, Chen C1, Dai Z, Deng Z, Pu J, Zhou Y, Li B, Wang Z#, Ran P#. The gut microbiome as a potential source of non-invasive biomarkers of chronic obstructive pulmonary disease. Front Microbiol. 2023. doi: https://doi.org/10.3389/fmicb.2023.1173614

6.      Cai S1, Gao J1, Liu X1, Yang J1, Feng D, Li G, Li S, Yang H, Wang Z, Yi X#, Zhou Y#. Seasonal Dynamics of the Upper Respiratory Tract Microbiome in Chronic Obstructive Pulmonary Disease. Int J Chron Obstruct Pulmon Dis. 2023 Jun 20;18:1267-1276. doi: 10.2147/COPD.S403198.

7.      Zeng Y, Wu R, Wang F, Li S, Li L, Li Y, Qin P, Wei M, Yang J, Wu J, Chen A, Ke G, Yan Z, Yang H, Chen Z, Wang Z, Xiao W, Jiang Y, Chen X, Zeng Z#, Zhao X#, Chen P#, Gong S#. Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice. Cell Host & Microbe. 2023. 31, 766–780. https://doi.org/10.1016/j.chom.2023.04.002

8.      Chen X, Wu R, Li L, Zeng Y, Chen J, Wei M, Feng Y, Chen G, Wang Y, Lin L, Luo H, Chen A, Zeng Z, He F, Bai Y, Zhang S, Han Y, Wang Z, Zhao X, Xiao W, Jiang Y, Gong S. Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation. Immunity. 2023. https://doi.org/10.1016/j.immuni.2023.01.015

9.      Li J, Chen Y, Li R, Zhang X, Chen T, Mei F, Liu R, Chen M, Ge Y, Hu H, Wei R, Chen Z, Fan H, Zeng Z, Deng Y, Luo H, Hu S, Cai S, Wu F, Shi N, Wang Z, Zeng Y, Xie M, Jiang Y, Chen Z, Jia W, Chen P. Gut microbial metabolite hyodeoxycholic acid targets TLR4/MD2 complex to attenuate macrophage pro-inflammatory activity and protect against sepsis. Molecular Therapy. 2023. doi: https://doi.org/10.1016/j.ymthe.2023.01.018

10.  Zheng H, Mai F, Zhang S, Lan Z, Wang Z, Lan S, Zhang R, Liang D, Chen G, Chen X, Feng Y. In silico method to maximise the biological potential of understudied metabolomic biomarkers: a study in pre-eclampsia. Gut. 2023. doi: 10.1136/gutjnl-2022-329312

11.  Qi Y, Zhu Z, Liu X, Yang J, Zhang W, Huang J, Li H, Guan W, Wang Z, Li Y. The effect of oral bacterial lysates on the respiratory microbiome in patients with chronic obstructive pulmonary disease exacerbations – A pilot study. Medicine in Microecology. 2022. 14,100067

12.  Gao J1, Zhao X1, Hu S1, Huang Z, Hu M, Jin S, Lu B, Sun K, Wang Z, Fu J, Weersma RK#, He X#, Zhou H#. Gut microbial DL-endopeptidase alleviates Crohn’s disease via the NOD2 pathway. Cell Host & Microbe. 2022. doi: 10.1016/j.chom.2022.08.002

13.  Yi X, Gao J, and Wang Z. The Human Lung Microbiome—A Hidden Link Between Microbes and Human Health and Diseases. iMeta. 2022 e33. doi: 10.1002/imt2.33

14.  He Z, Zeng Y, Li S, Lin L, Zhou R, Wang F, Yang W, Wu Y, Yang J, Chen A, Wang Z, Yang H, Zhao X, Xiao W, Li L, Gong S. Gut Commensal Fungi Protect Against Acetaminophen-Induced Hepatotoxicity by Reducing Cyp2a5 Expression in Mice. Front Microbiol. 2022 Jul 12;13:944416. doi: 10.3389/fmicb.2022.944416

15.  Li R, Yi X, Yang J, Zhu Z, Wang Y, Liu X, Huang X, Wan Y, Fu X, Shu W#, Zhang W#, Wang Z#. Gut Microbiome Signatures in the Progression of Hepatitis B Virus-Induced Liver Disease. Front Microbiol. 2022 Jun 6;13:916061. doi: 10.3389/fmicb.2022.916061

16.  Luo C, Zhu Y, Zhu Z, Li R, Chen G#, Wang Z#. A machine learning-based risk stratification tool for in-hospital mortality of intensive care unit patients with heart failure. Journal of Translational Medicine. 2022. 20(1):136. doi: 10.1186/s12967-022-03340-8

17.  Yi X, Liang JL, Su JQ, Jia P, Lu JL, Zheng J, Wang Z, Feng SW, Luo ZH, Ai HX, Liao B, Shu WS, Li JT, Zhu YG. Globally distributed mining-impacted environments are underexplored hotspots of multidrug resistance genes. The ISME Journal. 2022 Jun 10. doi: 10.1038/s41396-022-01258-z

18.  Yi X1, Li Y1, Liu H1, Liu X, Yang J, Gao J, Yang Y, Liang Z, Wang F, Chen D, Wang L, Shi W, Lam DCL, Stampfli MR, Jones PW, Chen R#, Wang Z#. Inflammatory Endotype Associated Airway Resistome in Chronic Obstructive Pulmonary Disease. Microbiology Spectrum. 2022. 21:e0259321. doi: 10.1128/spectrum.02593-21

19.  Li N1, Dai Z1, Wang Z, Deng Z, Zhang J, Pu J, Cao W, Pan T, Zhou Y, Yang Z, Li J, Li B, Ran P. Gut microbiota dysbiosis contributes to the development of chronic obstructive pulmonary disease. Respiratory Research. 2021. 22(1) 1-15

20.  Shen W, Qiu W, Liu Y, Liao W, Ma Y, He Y, Wang Z#, Zhou H#. Postnatal age is strongly correlated with the early development of the gut microbiome in preterm infants. Translational Pediatrics. 2021. 10(9), 2313.

21.  Chu Y1, Sun S1, Huang Y1, Gao Q1, Xie X1, Wang P1, Li J, Liang L, He X, Jiang Y, Wang M, Yang J, Chen X, Zhou C, Zhao Y, Ding F, Zhang Y, Wu X, Bai X, Wu J, Wei X, Chen X, Yue Z, Fang X, Huang Q#, Wang Z#, Huang R#. Metagenomic analysis revealed the potential role of gut microbiome in gout. npj Biofilms and Microbiomes. 2021. 7(1):66. doi: 10.1038/s41522-021-00235-2

22.  Li J, Lu J, Wang H, Fang Z, Wang X, Feng S, Wang Z, Yuan T, Zhang S, Ou S, Yang X, Wu Z, Du X, Tang L, Liao B, Shu W, Jia P, Liang JL. A comprehensive synthesis unveils the mysteries of phosphate-solubilizing microbes. Biological Reviews. 2021. https://doi.org/10.1111/brv.12779

23.  Liu H1, Liang Z1, Cao N1, Yi X1, Tan X, Liu Z, Wang F, Yang Y, Li C, Xiang Z, He Y, Su J, Wang Z#, Chen R#, Zhou H#. Airway bacterial and fungal microbiome in chronic obstructive pulmonary disease. Medicine in Microecology. 2021 Apr 16. P100335.

24.  Tian T, Shu B, Jiang Y, Ye M, Liu L, Guo Z, Han Z, Wang Z, Zhou X. An Ultralocalized Cas13a Assay Enables Universal and Nucleic Acid Amplification-Free Single-Molecule RNA Diagnostics. ACS Nano. 2020 Dec 17. https://doi.org/10.1021/acsnano.0c08165

25.  Liu H1, Zheng D1, Lin Y, Liu Z, Liang Z, Su J, Chen R, Zhou H#, Wang Z#. Association of sputum microbiome with clinical outcome of initial antibiotic treatment in hospitalized patients with acute exacerbations of COPD. Pharmacological Research. 2020 Jul 28. 160 (2020) 105095

26.  Wang Z1, Liu H1, Wang F1, Yang Y1, Wang X, Chen B, Stampfli MR, Zhou H, Shu W, Brightling CE, Liang Z, Chen R. A refined view of airway microbiome in chronic obstructive pulmonary disease at species and strain-levels. Frontiers in Microbiology. 2020 Jul 30. 11:1758. doi: 10.3389/fmicb.2020.01758

27.  Beech AS, Lea S, Kolsum U, Wang Z, Miller BE, Donaldson GC, Wedzicha JA, Brightling CE, Singh D. Bacteria and sputum inflammatory cell count; a COPD cohort analysis. Respiratory Research. 2020 Nov 1;21(1):289

28.  Haldar K1, George L1, Wang Z, Mistry V, Ramsheh MY, Free RC, John C, Reeves NF, Miller BE, Tal-Singer R, Webb AJ, Brookes AJ, Tobin MD, Singh D, Donaldson GC, Wedzicha JA, Brown JR, Barer MR, Brightling CE. The sputum microbiome is distinct between COPD and health, independent of smoking history. Respiratory Research. 2020 Jul 14;21(1):183

29.  Wang Z1, Wu J1, Li D, Tang X, Zhao Y, Cai X, Chen X, Chen X, Huang Q, Huang R. Traditional Chinese medicine Biqi capsule compared with leflunomide in combination with methotrexate in patients with rheumatoid arthritis: a randomized controlled trial. Chinese Medicine. 2020 Apr 23. 15:36

30.  Yuan C, Tian T, Sun J, Hu M, Wang X, Xiong E, Cheng M, Bao Y, Lin W, Jiang J, Yang C, Chen Q, Zhang H, Wang H, Wang X, Deng X, Liao X, Liu YH, Wang Z#, Zhang G#, Zhou X#. Universal and Naked-Eye Gene Detection Platform Based on CRISPR/Cas12a/13a System. Analytical Chemistry. 2020 Feb 7. doi: 10.1021/acs.analchem.9b0559

31.  Nixon CC, Mavigner M, Sampey GC, Brooks DA, Spagnuolo RA, Irlbeck DM, Mattingly C, Ho PT, Schoof N, Cammon CG, Tharp GK, Kanke M, Wang Z, Cleary RA, Upadhyay AA, De C, Wills SR, Falcinelli SD, Galardi C, Walum H, Schramm NJ, Deutsch J, Lifson JD, Fennessey CM, Keele BF, Jean S, Maguire S, Liao B, Browne EP, Ferris RG, Brehm JH, Favre D, Vanderford TH, Bosinger SE, Jones CD, Routy J, Archin NM, Margolis DM, Wahl A, Dunham RM, Silvestri G, Chahroudi A, Garcia JV. Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo. 2020. Nature. 578(7793):160-165

32.  Washburn ML, Wang Z, Walton AH, Geodegebuure SP, Figueroa DJ, Van Horn S, Grossman J, Remlinger K, Madsen H, Brown JR, Srinivasan R, Wolf A, Yi V, Hawkins WG, Field RC, Hotchkiss RS. CD4 and CD8 T-cell and monocyte specific RNA-Seq analysis in septic and non-septic critically-ill patients and in patients with cancer. 2019. Journal of Immunology. 203(7):1897-1908

33.  Wang Z, Maschera B, Lea S, Kolsum U, Michalovich D, Van Horn S, Traini C, Brown JR, Hessel EM, Singh D. Airway host-microbiome interactions in chronic obstructive pulmonary disease. 2019. Respiratory Research. 20(1):113

34.  Wang Z1, Arat S1, Magid-Slav M, Brown JR. 2018. Meta-analysis of human gene expression in response to Mycobacterium tuberculosis infection reveals potential therapeutic targets. BMC Systems Biology. 12(1):3. doi: 10.1186/s12918-017-0524-z

35.  Wang Z, Saha S, Van Horn S, Thomas E, Traini C, Sathe G, Rajpal DK, Brown JR. 2017. Gut microbiome differences between metformin and liraglutide treated T2DM subjects. Endocrinology, Diabetes & Metabolism. 10.1002/edm2.9.

36.  Wang Z, Wu M. 2017. Comparative genomic analysis on Acanthamoeba endosymbionts highlights the role of amoebae as a melting pot shaping the Rickettsiales evolution. Genome Biology and Evolution. 9:3214-3224

37.  Cichewicz K, Garren EJ, Adiele C, Aso Y, Wang Z, Wu M, Birman S, Rubin GM, Hirsh J. 2016. A New Brain Dopamine Deficient Drosophila and its Pharmacological and Genetic Rescue. Genes Brain Behavior. doi: 10.1111/gbb.12353

38.  Wang Z, Wu M. 2015. An integrated phylogenomic approach toward pinpointing the origin of mitochondria. Scientific Reports. doi:10.1038/srep07949

39.  Wang Z, Wu M. 2014. Phylogenomic reconstruction indicates mitochondrial ancestor was an energy parasite. PLoS ONE. 9(10): e110685

40.  Wang Z, Wu M. 2014. Complete genome sequence of the endosymbiont of Acanthamoeba strain UWC8, an amoeba endosymbiont belonging to the “Candidatus Midichloriaceae” family in Rickettsiales. Genome Announcements. 2(4):e00791-14.

41.  Kopac S1, Wang Z1, Wiedenbeck J, Sherry J, Wu M, Cohan FM. 2014. Genomic heterogeneity and ecological speciation within one subspecies of Bacillus subtilis. Applied and Environmental Microbiology. 80(16):4842-53

42.  Lin W1, Deng A1, Wang Z, Li Y, Wen T, Wu L, Wu M, Pan Y. 2014. Genomic insights into the uncultured genus “Candidatus Magnetobacterium” in the phylum Nitrospirae. The ISME Journal. doi: 10.1038/ismej.2014.94

43.  Wang Z, Wu M. 2013. A phylum-level bacterial phylogenetic marker database. Molecular Biology and Evolution. 30(6):1258-62

44.  Wang Z, Kadouri DE, Wu M. 2011. Genomic insights into an obligate epibiotic bacterial predator: Micavibrio aeruginosavorus ARL-13. BMC Genomics. 12:453

45.  Luo X, Wang Z, Dai J, Zhang L, Fang C. 2010. Cohnella damensis sp. nov., a motile xylanolytic bacteria isolated from a low altitude area in Tibet. Journal of Microbiology and Biotechnology. 20:410-414

46.  Luo X, Wang Z, Dai J, Zhang L, Li J, Tang Y, Wang Y, Fang C. 2010. Pedobacter glucosidilyticus sp. nov., isolated from dry riverbed soil. International Journal of Systematic and Evolutionary Microbiology 60:229-233

 


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