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2. Lodish H et al, Molecular Cell Biology. 5th ed(2004), W. H. Freeman and Company, New York
3. A1berts B et al£®Essential Cell Biology. 2nd ed£¨2003£©, Garland Inc£¬ publishing Inc., New York and London
4. Karp G, Cell and Molecular Biology£ºconcepts and experiments. 3rd ED. 2006, John Wiley£¦Sons Inc, New York
5. Donaldson A, Blow JJ. The regulation origin activation[J] Curr Opin in Gene Dev, 1999, 9:62-68.
6. Princes J. Cyclins and cyclin-dependent kinase: a biochemical view[J]. Biochem J. 1995, 308:697-711.
7. Elledge SJ. Mitotic arrest: Mad2 provents sleepy from waking up the APC[J]. Science, 1998, 279:999-1000.